Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot
نویسندگان
چکیده
1Department of Physics and 3Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 2Department of Chemistry, University of Texas at Austin, Austin, TX 78712 #Present address: Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore MD 21218 ‡Present address: Division of Physics & Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
منابع مشابه
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How RNA sequences fold to specific tertiary structures is one of the key problems for understanding their dynamics and functions. Here, we study the folding process of an H-type RNA pseudoknot by performing a large-scale all-atom MD simulation and bias-exchange metadynamics. The folding free energy landscapes are obtained and several folding intermediates are identified. It is suggested that th...
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تاریخ انتشار 2017